[Postdoc] UCSF cardiac physiology and pathology
2470
Postdoctoral Scholar – Cardiac Electrophysiology & Arrhythmia Mechanisms (UCSF Cardiology / CVRI)
Position summary
We are seeking a highly motivated Postdoctoral Scholar to join a multidisciplinary research program at the University of California, San Francisco (UCSF) focused on cardiac physiology and pathology, with an emphasis on cardiac rhythm disorders including sinus node dysfunction, atrial fibrillation (AF), and ventricular tachyarrhythmias (VT). Our lab integrates genetics, quantitative electrophysiology, and mechanistic studies of cardiac remodeling across development and aging to define disease mechanisms and identify new therapeutic strategies.
Research environment and approaches
The successful candidate will join an interactive team within the UCSF Cardiology Division and the Cardiovascular Research Institute (CVRI). Projects may involve combinations of:
Preferred qualifications
We are looking for candidates with strong experimental rigor and a track record of productivity. Ideal applicants will have:
Hands-on experience with one or more of the following is a plus:
What we offer
A mechanistically driven, collaborative environment with access to state-of-the-art UCSF resources
Strong mentorship toward first-author publications, fellowship applications, and career development
Opportunities to lead projects that connect molecular mechanisms to physiologic arrhythmia phenotypes across scales
How to apply
Please email a single PDF to 1point3acres.com including:
Position summary
We are seeking a highly motivated Postdoctoral Scholar to join a multidisciplinary research program at the University of California, San Francisco (UCSF) focused on cardiac physiology and pathology, with an emphasis on cardiac rhythm disorders including sinus node dysfunction, atrial fibrillation (AF), and ventricular tachyarrhythmias (VT). Our lab integrates genetics, quantitative electrophysiology, and mechanistic studies of cardiac remodeling across development and aging to define disease mechanisms and identify new therapeutic strategies.
Research environment and approaches
The successful candidate will join an interactive team within the UCSF Cardiology Division and the Cardiovascular Research Institute (CVRI). Projects may involve combinations of:
- Molecular and cell biology approaches to define pathways governing rhythm stability and remodeling.
- Genetic and genome-engineering strategies (e.g., CRISPR-based editing, knockouts/knock-ins) in mammalian cells and/or model systems.
- Electrophysiology and calcium signaling assays (cellular and tissue-level) relevant to arrhythmia triggers and substrates.
- Studies spanning developmental biology, aging biology, and disease progression.
- Opportunities for training in and collaboration on advanced imaging and quantitative analysis pipelines used to interrogate conduction, automaticity, and arrhythmogenesis.
Preferred qualifications
We are looking for candidates with strong experimental rigor and a track record of productivity. Ideal applicants will have:
- PhD (or equivalent) in cardiac physiology, molecular/cell biology, biomedical engineering, genetics, pharmacology, or related fields.
- Strong molecular biology background, including design and assembly of DNA constructs (e.g., cloning, viral vectors, plasmid engineering).
- Mammalian cell culture experience, including transfection/transduction and optimization of expression systems.
- Prior experience with genome manipulation (e.g., CRISPR/Cas9, gene knockouts/knock-ins, siRNA/shRNA, AAV/lentiviral delivery).
Hands-on experience with one or more of the following is a plus:
- Cardiomyocyte biology (primary cardiomyocytes and/or hiPSC-derived cardiomyocytes)
- Calcium handling / excitation–contraction coupling assays (e.g., indicators, imaging, analysis)
- Cardiac electrophysiology methods (patch clamp, MEA, optical mapping, ECG/telemetry, pacing)
- Mouse models and cardiac phenotyping (echo, Langendorff, tissue processing).
What we offer
A mechanistically driven, collaborative environment with access to state-of-the-art UCSF resources
Strong mentorship toward first-author publications, fellowship applications, and career development
Opportunities to lead projects that connect molecular mechanisms to physiologic arrhythmia phenotypes across scales
How to apply
Please email a single PDF to 1point3acres.com including:
- CV
- Research statement describing research interests and fit
- Contact information for 2–3 references
