University of Virginia YangLab is Recruiting PhD/Postdocs/technician(Long time)
5202
Research Overview: The Yang Lab is focused on studying the molecular mechanisms of cellular stress response pathways. We use an interdisciplinary approach, integrating structural biology (Cryo-EM/Cryo-ET), computational biology (de novo protein design) biochemistry (protein characterization), and cell biology (fluorescent imaging). Our goal is to modulate those stress response pathways in physiological and pathological conditions, potentially leading to the development of novel therapeutics for related human diseases, including neurodegeneration, metabolic disorders, and cancer. In addition, we have established close collaborations with experts in disease-relevant mouse models to complement our mechanistic findings.
Expected Candidates:
· Fellow with expertise in de novo protein design
Design novel binders to target biologically important protein complexes involved in cellular stress response.
Develop methods harnessing protein design to advance high-resolution cryo-EM studies of challenging protein targets. This includes the design of scaffolds, fusion proteins, or binding partners to stabilize samples for structural determination.
· Fellow with expertise in cryo-electron microscopy
Expertise in structural biology, molecular biology, or biochemistry
· We also welcome applications from individuals interested investigating the fundamental aspects of any significant biological processes. Candidates with backgrounds and expertise in cell culture are preferred.
Those positions offer exciting opportunities to contribute to cutting-edge structural biology and protein engineering research in a collaborative environment.
Expected Candidates:· Fellow with expertise in de novo protein design
Design novel binders to target biologically important protein complexes involved in cellular stress response.
Develop methods harnessing protein design to advance high-resolution cryo-EM studies of challenging protein targets. This includes the design of scaffolds, fusion proteins, or binding partners to stabilize samples for structural determination.
· Fellow with expertise in cryo-electron microscopy
Expertise in structural biology, molecular biology, or biochemistry
· We also welcome applications from individuals interested investigating the fundamental aspects of any significant biological processes. Candidates with backgrounds and expertise in cell culture are preferred.
Those positions offer exciting opportunities to contribute to cutting-edge structural biology and protein engineering research in a collaborative environment.
